About Database

For each study, after removing outliers (see QC section), each of 23 demographic effects was assessed on a gene-by-gene basis. We recorded which demographics were significant for gene, where significance was defined as p<.01, FC>1.3. For each of comparison of effect sizes, all demographics were analyzed using two levels. Continuous variables and ordered categorical variables were cut at values as close as possible to the median (e.g. PMI>30 vs. PMI<30; Drug Use = ‘Heavy’ vs. Drug Use = ‘None, Light, Moderate’). Some of the demographics were analyzed using the whole patient set in a study, while some were analyzed within each disease group to avoid confounding of the demographic effect and the disease effect. The following list shows the demographic analyses that were performed.

Using All Samples

Age >45 (Y/N)
PMI > 30 (Y/N)
Brain pH > 6.5 (Y/N)
Left Brain (Y/N)
Sex (M/F)
Smoking at Time of Death (Y/N)
Hsv1 OD (High/Low)
Hsv2 OD (High/Low)

Within Bipolar

Bipolar Severity (Severe/Other)
Bipolar Heavy Alcohol Use (Y/N)
Bipolar Heavy Drug Use (Y/N)
Bipolar Psychotic Feature (Y/N)
Bipolar Sudden Death (Y/N)
Bipolar Suicide Status (Y/N)

Within Schizophrenia

Schizophrenia Severity (Severe/Other)
Schizophrenia Heavy Alcohol Use (Y/N)
Schizophrenia Heavy Drug Use (Y/N)
Schizophrenia (Paranoid/Undiff)
Schizophrenia Sudden Death (Y/N)
Schizophrenia Suicide (Y/N)

Within Depression

Depression Heavy Alcohol Use (Y/N)
Depression Heavy Drug Use (Y/N)
Depression Suicide (Y/N)

Demographic Analysis